Cytokine Storm Syndrome

Cytokine Storm Syndrome

细胞因子风暴综合症
生物化学

原价：

￥ 2595.00

售价：

优惠

平台大促低至8折优惠

发货周期：预计8-10周发货

作者

Cron, Randy Q.(编辑);Behrens, Edward M.(编辑)

出版社

Springer Berlin Heidelberg

出版时间

2020年09月20日

装帧

平装

ＩＳＢＮ

9783030220969

复制

页码

617

开本

9.21 x 6.14 x 1.29

语种

英文

版次

2019

综合评分

暂无评分

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图书简介

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.

Part I: Background.- 1.Cytokines in Cytokine Storm Syndrome.- 2. History of hemophagocytic lymphohistiocytosis.- 3.The History of Macrophage Activation Syndrome in Autoimmune Diseases.- 4. Clinical Features of Cytokine Storm Syndrome.- 5.Laboratory Features and Pathology of the Cytokine Storm Syndromes.- 6.Criteria for Cytokine Storm Syndromes.- Part II: Genetics of Cytokine Storm Syndromes.- 7.Genetics of Acquired Cytokine Storm Syndromes.- 8.Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis.- Part III: Immunology of Cytokine Storm Syndromes.- 9.CD8+ T cell biology in cytokine storm syndromes.- 10.Immunology of Cytokine Storm Syndromes: Natural Killer Cells.- 11.Myeloid cells in the immunopathogenesis of cytokine storm syndromes.- 12.Cytokines in Cytokine Storm Syndrome.- 13. Primary Immunodeficiencies and Cytokine Storm Syndromes.- Part IV: Infectious Triggers of Cytokine Storm Syndromes.- 14.Infectious Triggers of Cytokine Storm Syndromes: Herpes Virus Family (non-EBV).- 15.Cytokine Storm Syndromes Associated with Epstein Barr Virus.- 16.Cytokine Storm Syndrome Associated with Hemorrhagic Fever and Other Viruses.- 17.Cytokine Storm Syndrome as a manifestation of Primary HIV Infection.- 18. Bacteria-Associated Cytokine Storm Syndrome.- 19.Zoonotic Bacterial Infections Triggering Cytokine Storm Syndrome.- 20. Parasitic and Fungal Triggers.- Part V: Rheumatic Triggers of Cytokine Storm Syndromes.- 21.Cytokine Storm Syndrome associated with Systemic Juvenile Idiopathic Arthritis.- 22. Systemic Lupus Erythematosus and Cytokine Storm.- 23. Kawasaki Disease.- 24.The Intersections of Autoinflammation and Cytokine Storm.- 25. Macrophage Activation Syndrome in the Setting of Rheumatic Diseases.- Part VI: Other Triggers of Cytokine Storm Syndromes.- 26. Hemophagocytic lymphohistiocytosisin the context of hematological malignancies and solid tumors.- 27.Cytokine Storm and Sepsis induced Multiple Organ Dysfunction Syndrome.- Part VII: Murine Models of Cytokine Storm Syndrom.- 28. Murine Models of Familial Cytokine Storm Syndromes.- 29.Murine Models of Secondary Cytokine Storm Syndromes.- Part VIII: Therapy of Cytokine Storm Syndromes.- 30.Etoposide Therapy of Cytokine Storm Syndromes.- 31. IL-1 Family Blockade.- 32.IL-6 Blockade.- 33. Alternative Therapies for Cytokine Storm Syndromes.- 34.Salvage Therapy and Allogeneic Hematopoietic Cell Transplantation for the Severe Cytokine Storm Syndrome of Hemophagocytic Lymphohistiocytosis.

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