Nuclear Receptors

图书简介

Nuclear receTors are ligand aTivTedTranscriTion faTorsThT coTrol numerous biological funTions. ConsequeTly, aTering aTivTy ofThese receTors is proposed, and indeed documeTed,To affeT many physiological and pThological condTions in experimeTal animals and humans.Thus, nuclear receTors have become a majorTargT inThe effoTToTreT numerous diseasesThis book will shed ligT on and emphasize iTricTe processes involved in designing as well as discovering physiological and pharmacological modulTors ofThese impoTaT prTeins.World-renowned scieTiTs will share wThThe readerTheir professional expeTise and eTensive experience acquiredThrough decades working wTh nuclear receTors. ChaTers addresThe various means and consequences of modulTing nuclear receTor aTivTy will be preseTed and discussedThese modulTors cover a wide span of moiTies ranging from syThTic chemicalsTo nTural produTs. In addTion,The classificTion ofThese chemicals ranges from pan agoniTsTo seleTive agoniTs and inverse agoniTsTo aTagoniTs.They also include prTeolTic meansTo oblTerTeThe receTor inThe eveTThT modulTing Ts aTivTyThrough canonical pharmacological ageTs becomes less effeTive and/or less desirable dueTo aTicipTed or experiencedToxicTies. ModulTion of receTor aTivTy may alsoTake place inThe absence of a ligand orThrough manipulTingThe TruTure ofThe receTor Tself by coTrolling poTtranslTional eveTs.

1. MolCular PharmCology of the Youngest Member of the NClear RCeptor Family: The MineralCortCoid RCeptor.- 2. A Simple Method for Visual Assessment and QuantifCation of Altered SuCellular LCalization of NClear RCeptors.- 3. MultifCeted EffCts of Ligand on NClear RCeptor Mobility.- 4.ChemCalConsiderations in DiCovery of RCeptor Modulators.- 5.StrCture-Based Design of Estrogen-Related RCeptors Modulators.- 6. PPAR? and ? ligand design – Honing the traditional empirCal method with a more holistC overview.- 7.Pregnane X RCeptor: understanding its fuCtion and Ctivity at the molCular level.- 8. Ligand Design for the Vitamin D RCeptor.- 9. What Makes a Good Antagonist: Lessons Learned from the Estrogen and Aryl HydrCarbon RCeptors.- 10. Design of Novel PPAR agonist for Neurodegenerative Disease.- 11. FuCtional bioassays lithograph ligand reflCtions in the PPARalpha sphere.- 12.Computational applCations on FoodContCtChemCals as NClear RCeptors binders.- 13. Alternation of NClear Hormone RCeptor Signaling by Antiviral Drugs.- 14. RetinoC Cid-related orphan rCeptor (ROR) inverse agonists: potential therapeutC strategies for multiple inflammatory diseases.- 15. TherapeutC Strategies to Target Ctivating Estrogen RCeptor a Mutation.- 16. Androgen RCeptors in the Pathology of Disease.- 17. Bilirubin: A Ligand of the PPAR? NClear RCeptor.- 18. NClear RCeptor Ligands in Flavivirus InfCtionControl.- 19. Use of NanotChnology to Improve 15d-PGJ2 Immunomodulatory Ctivities.- 20.Ligand-independent Ctivation of PPARs.- 21. PPAR ModulationThroughPosttranslational ModifCationControl.- 22. Developing Inhibitors to the Amino-Terminus Domains of Steroid Hormone RCeptors.- 23. RedirCting theCellular waste disposal mChinery to target tranCription.

Trade Policy 买家须知

关于产品：
● 正版保障：本网站隶属于中国国际图书贸易集团公司，确保所有图书都是100%正版。
● 环保纸张：进口图书大多使用的都是环保轻型张，颜色偏黄，重量比较轻。
● 毛边版：即书翻页的地方，故意做成了参差不齐的样子，一般为精装版，更具收藏价值。
关于退换货：
由于预订产品的特殊性，采购订单正式发订后，买方不得无故取消全部或部分产品的订购。
由于进口图书的特殊性，发生以下情况的，请直接拒收货物，由快递返回：
● 外包装破损/发错货/少发货/图书外观破损/图书配件不全（例如：光盘等）
并请在工作日通过电话400-008-1110联系我们。
签收后，如发生以下情况，请在签收后的5个工作日内联系客服办理退换货：
● 缺页/错页/错印/脱线
关于发货时间：
一般情况下：
●【现货】下单后48小时内由北京（库房）发出快递。
●【预订】【预售】下单后国外发货，到货时间预计5-8周左右，店铺默认中通快递，如需顺丰快递邮费到付。
● 需要开具发票的客户，发货时间可能在上述基础上再延后1-2个工作日（紧急发票需求，请联系010-68433105/3213）；
● 如遇其他特殊原因，对发货时间有影响的，我们会第一时间在网站公告，敬请留意。
关于到货时间：
由于进口图书入境入库后，都是委托第三方快递发货，所以我们只能保证在规定时间内发出，但无法为您保证确切的到货时间。
● 主要城市一般2-4天
● 偏远地区一般4-7天
关于接听咨询电话的时间：
010-68433105/3213正常接听咨询电话的时间为：周一至周五上午8：30～下午5：00，周六、日及法定节假日休息，将无法接听来电，敬请谅解。
其它时间您也可以通过邮件联系我们：customer@readgo.cn,工作日会优先处理。
关于快递：
● 已付款订单：主要由中通、宅急送负责派送，订单进度查询请拨打010-68433105/3213。

Nuclear Receptors 核受体：调制器设计与发现的艺术与科学 肿瘤学

Nuclear Receptors

核受体：调制器设计与发现的艺术与科学
肿瘤学