Tumor Suppressor Par-4
肿瘤抑制因子 Par-4：癌症与其他疾病中的作用
肿瘤学
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出版时间
2021年09月27日
装 帧
精装
页 码
450
语 种
英文
版 次
2021
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图书简介
Par-4 is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells.
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